Definition

1. Noun:
   • A chromosome lacking a centromere: An acentric chromosome is a structural abnormality in which a chromosome fragment is produced without a centromere. The centromere is a specialized DNA sequence essential for proper chromosome segregation during cell division.

Usage Examples

• Noun:
  • The formation of an acentric chromosome fragment is a common consequence of ionizing radiation.
  • During genetic analysis, the researcher identified an acentric chromosome in the cell sample.
  • Acentric chromosomes are typically lost during cell division because they cannot attach to the spindle apparatus.

Advanced Usage

• In a research context: The term is used to describe a specific type of chromosomal aberration studied in genetics, cytogenetics, and cancer biology.
  • The study focused on the mechanisms that generate acentric chromosomes and double-minute chromosomes.

Variants and Related Words

• Acentric (adj): Describing a chromosome or fragment that lacks a centromere.
  • The acentric fragment was observed under the microscope.

Synonyms

• Centromere-lacking chromosome: A descriptive synonym.
• Acentric fragment: Often used interchangeably, though "fragment" emphasizes it is a piece of a chromosome.

Related Terms (Not Synonyms)

• Centromere: The essential region missing in an acentric chromosome.
• Dicentric chromosome: A chromosome with two centromeres, another type of abnormality.
• Micronucleus: A small nucleus that can form around an or fragment after cell division.

Noun

1. a chromosome lacking a centromere